Knowledge Library

  In January, Phacilitate Leaders World & World Stem Cell Summit 2020 brought together the entire ecosystem of the advanced therapies industry from all corners of the globe to continue to build strong partnerships and collaborations to Miami, FL.  With so many great topics covered, common theme was innovation in research through to manufacturing and commercialization.  …Read More >

  This article features: Bai-wei Gu, Head of the Cell Line Development Group, Juan Lagos, Head of Upstream Processing, and Matthew Weaver, Head of Downstream Processing at WuXi Advanced Therapies covering how to accelerate development and manufacturing platforms for viral vectors. Developing innovative advanced therapies is one of our greatest opportunities to dramatically improve patients’ …Read More >

Abstract: Developing innovative advanced therapies is one of our greatest opportunities to dramatically improve patients’ lives. In this webinar, we will discuss our recent technical advancement on efficient viral vector manufacturing process development. From cell line development, suspension culture of HEK293 cells, transfection, to cell culture optimization and purification process development, a series of progress …Read More >

  Summary of the Presentation given at Phacilitate in Miami (2020): – Established suspension HEK293 cell line – In-stock raw materials with established batch records – State-of-the-art GMP manufacturing facilities with enhanced scalability that range up to 1000L – Established and dedicated process & analytical development teams – Strong and dedicated technical guidance including regulatory …Read More >

From clarification to separation of empty and full capsids, each downstream processing step has its challenges in viral vector manufacturing at a CDMO.