Plasmid Manufacturing

 

End-to-end solutions for plasmid manufacturing

Expert plasmid engineering and production from research commercial GMP grade. Off the shelf and custom plasmids are available within impressive timelines.

Our AAVEX™ and LentiVEX™ plasmids are pre-validated for use with the WuXi Advanced Therapies’ viral vector manufacturing and testing platforms, delivering fully integrated high titre, scalable and cost-effective viral vector solutions to pioneering cell and gene therapy developers.

Get the best results with high-performance plasmids and comprehensive technical support from our expert scientists.

Exceptional plasmids for every step of your therapeutic journey.

Our integrated capabilities allow for a seamless single-source approach — from raw and starting material characterization and process control strategies through plasmid growth, purification and final fill, ensuring efficient plasmid production and release tailored to meet each customer’s needs.

High-quality plasmids

Our AAVEX and LentiVEX plasmids have been engineered for high yield and positive safety profiles and are available royalty free at research, clinical GMP and commercial GMP grades.

Integrated testing

WuXi Advanced Therapies carries out all required quality control assays for bacterial strain bank testing and product release. Testing is integrated throughout the plasmid manufacturing process to ensure high product purity and homogeneity, low endotoxin levels and final product stability.

Impressive timelines

We actively work to reduce timelines for our customers. Off the shelf orders can be fulfilled immediately, while custom GMP grade plasmids are delivered within 4 months.

Comprehensive regulatory support

Our quality systems are designed to meet the most stringent global regulatory standards. We use our extensive experience in the cell and gene therapy industry to guide our customers through to regulatory approval of their novel therapy.

A turnkey solution to accelerate the development and commercialization of ground-breaking cell and gene therapies

 

We support our customers through their whole therapeutic journey from construct design and optimization and cell line development, through preclinical plasmid and viral vector production, to GMP plasmid, viral vector and cell therapy manufacture, testing and product release.

Case Study – Accelerating the development of advanced therapies from discovery to biomanufacture

“We’ve been extremely pleased with the work conducted by OXGENE to promote the pre-clinical development of our next generation CAR-T cell therapies. Working together with OXGENE in the UK, and later with WuXi Advanced Therapies in China has helped to accelerate the development of these promising clinical candidates.”

– Jae Won Lee
CEO, TiCARos

On-demand Webinar

Improving Plasmid Design, Process and Manufacturing to Improve Viral Vector Yield 

 

Watch Now >

 

Featured Plasmid Resources

Discover WuXi Advanced Therapies’ plasmid offerings though our engaging and informative resources.

Flyer – Lenti Plasmids

OXGENE’s proprietary cell and gene therapy manufacturing solutions help pioneering companies achieve high-titre, scalable and cost-effective viral vector production. Streamlined ordering and manufacturing processes accelerate turnaround times and expedited local and international delivery for both standard and custom plasmids at all grades. Planned local stocks of standard plasmids will further reduce delivery times. OXGENE’s plasmids are validated and optimized for use on WuXi Advanced Therapies’ (WuXi ATU) Lentiviral GMP manufacturing platform, offering a seamless transition with reduced technology transfer times to high quality, high yield GMP grade lentiviral production for clinical or commercial use. 

Flyer – AAV Plasmids

OXGENE’s proprietary cell and gene therapy manufacturing solutions help pioneering companies achieve high-titre, scalable and cost-effective viral vector production. Streamlined ordering and manufacturing processes accelerate turnaround times and expedited local and international delivery for both standard and custom plasmids at all grades. Planned local stocks of standard plasmids will further reduce delivery times. OXGENE’s plasmids are validated and optimized for use on WuXi Advanced Therapies’ (WuXi ATU) AAV GMP manufacturing platform, offering a seamless transition with reduced technology transfer times to high quality, high yield GMP grade AAV production for clinical or commercial use.

Article – Overcoming the Challenges of Large Scale Plasmid Production – EBR

Gene therapy involves inserting a new section of DNA into a patient’s cells. This DNA is delivered by viral vectors, which are usually built from plasmids. Plasmids are small sections of genetic material that can be combined to contain all the genes necessary to deliver the gene therapy. Many challenges associated with manufacturing therapies on a large scale are caused by difficulties when working with plasmids. When manufacturing a plasmid, the final product must be consistent across batches and must not have altered genetic material or other variations that affect quality. 

Plasmid Order Form

We provide off-the-shelf and custom plasmids to support every step of your therapeutic development journey. OXGENE’s plasmids are manufactured by WuXi Advanced Therapies in a regulatory-friendly antibiotic-free process.

Off-the-shelf AAV and Lentiviral packaging plasmids are available royalty free for international delivery within 2 weeks.

Custom AAV and Lentiviral plasmids are available at Research, Clinical GMP and Commercial GMP grades, and are available for international delivery within 3 to 5 months.

Plasmid Order Form

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